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KMID : 0381019950280040291
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Korean Journal of Nutrition
1995 Volume.28 No. 4 p.291 ~ p.297
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Effect of Protein and Protein Hydrolysate on Nitrogen Metabolism in Rats with Gastric Ulcer Induced by Restraint and Water-lmmersion Stress
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김창임/Kim, Chang Im
이연숙/Lee, Yeonsook
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Abstract
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This study aimed to verify the nutritional and curative effects of protein hydroysate in rats model with gastric ulcer induced by restraint and water-immersion stress. Sprague-Dawley, famale rats weighing approximtely 200g were forced in 5$\times$ 수식 이미지5$\times$ 수식 이미지15cm plexiglas cage. The restraint and water immersion stress was carried at 20$\pm$ 수식 이미지2$^{\circ}C$ 수식 이미지 for 8-hours. After stress 4 kinds of diets(10% casein, 20% casein, 10% casein hydrolysate, 20% casein hydrolysate) were given for 5 days. In the gastric ulcer rats model, the growth, gastric emptying rate, trypsin activity in gastrointestinal content, plasma total protein, albumin, $\alpha$ 수식 이미지-amino-N, UUN, creatinine and hydroxyproline of the urine and nitrogen retention were analyzed for nutritional effects of dietary nitrogen levels(10%, 20%) and sources (casein, casein hydrolysate). The results were as follows ; In gastric ulcer rats model, severeness of ulcer, plasma protein, gastric emptying rate, nitrogen retention rate were not different between 20% casein-fed group and 20% casein hydrolysatefed group. But 10% casein hydrolysate-fed group had more curative group. The casein hydrolysate diet-fed group was lower trysin activity in small intestianl content than the casein-fed group, at both casein level(10%, 20%). Finally at 20% levels, there was no difference between casein and casein hydrolysate diet, but 10% level, casein hydrolysate diet was more curative of ulcer than casein diet in gastric ulcer rat model. The results of this study provide useful information concerning diet therapy for the patients with gastrointestinal diseases and the field of enteral diet materials.
Casein; Casein hydrolysate; Gastric ulcer; Restraint; Water-immersion stress; Nitrogen metabolism
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KEYWORD
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Casein, Casein hydrolysate, Gastric ulcer, Restraint, Water-immersion stress, Nitrogen metabolism
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